Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds ?-tubulin with Kd of 0.4 ?M in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 ?M, and also disrupts tumor vasculature. Phase 3.
