Navitoclax (ABT-263)

Navitoclax (ABT-263)

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Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ? 0.5 nM, ?1 nM and ?1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

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